이창훈

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이창훈
소속 융복합대학
부서 기초학부
전공분야 생물-생화학 구조생물학
DGIST Email ID leech
홈페이지

UGRP 주제

관심연구분야

    현상: 
    단백질의 구조-기능 관계, 구조기반 신약설계 Structure-Function relationship, Structure-based Drug Design
    피부 장벽 형성 및 퇴행, 피부노화
    외피계 구조 형성, 색소 합성 및 이동
    외피계-내분비계 및 외피계-신경계의 생리학적 상호작용

    대상: 
    피부, 외피계 및 외피계 모사 시스템 Integumentary system and its mimetic systems in vitro or ex vivo
    Keratins, Matrix Matalloproteinases (MMPs), Monoamineoxidases (MAOA and MAOB), etc.
    도구: 
    단백질 생화학, 구조생물학, 세포생물학

확장 관심분야

     현상: 
     단백질 설계 및 단백질 회로 설계, Protein design and biocircuit design
     대상: 
     Fluorescence or Bioluminescence proteins, Nanobodies and single chain antibodies
     도구: 
     전자현미경

학습 관심분야

     피부학
     합성생물학
     생명과학 실험 교육
     생물심리학 (창의성, 공격성)

주요논문

• Im S, Jeong J, Jin G, Yeom J, Jekal J, Lee SI, Cho JA, Lee S, Lee Y, Kim DH, Bae M, Heo J, Moon C*, Lee CH*. (2019) MAOA variants differ in oscillatory EEG & ECG activities in response to aggression-inducing stimuli. Scientific Reports, 2680

• Im S, Jeong J, Jin G, Yeom J, Jekal J, Lee SI, Cho JA, Lee S, Lee Y, Kim DH, Bae M, Heo J, Moon C*, Lee CH*. (2019) A novel supportive assessment for comprehensive aggression using EEG and ECG. Neurosci Lett. 694:136-142.

• Im S, Jeong J, Jin G, Yeom J, Jekal J, Lee SI, Cho JA, Lee S, Lee Y, Kim DH, Bae M, Heo J, Moon C*, Lee CH*. (2018) Gender Differences in Aggression-related Responses on EEG and ECG. Exp Neurobiol. 27: 526–538.

• Kim, KH, Chung, WS, Kim, KS, Lee, IS, Park, JY, Jeong, HS, Lee, CH*, Jang, HJ* (2015) Transcriptomic analysis reveals Wound healing of Morus alba roots extract by up-regulating keratin filament and CXCL12/CXCL4 signaling. Phytother Res. 29:1251-1258.

• Kim, JS. Lee, CH, Su, BY, Coulombe, PA (2012) Mathematical modeling of the impact of actin and keratin filaments on keratinocyte cell spreading. Biophys J. 103:1828-1838.

Lee, CH, Kim, MS, Chung, BM, Leahy, DJ, Coulombe, PA (2012) Structural basis for heteromeric assembly and perinuclear organization of keratin filaments. Nat. Struct. Mol. Biol. 19:707-715.

• Coulombe, PA, Lee, CH (2012) Defining Keratin Protein Function in Skin Epithelia: Epidermolysis Bullosa Simplex and Its Aftermath. J. Invest. Dermatol. 132:763-765.

• Kim JS, Lee CH, Coulombe PA (2010) Modeling the self-organization property of keratin intermediate filaments. Biophys J. 99:2748-2756.

Lee, CH, Coulombe, PA (2009) Self-organization of keratin intermediate filaments into crosslinked networks. J. Cell Biol. 186:409-421.

• Kim S, Kellner J, Lee CH, Coulombe PA. (2007) Interaction between the keratin cytoskeleton and eEF1Bgamma affects protein synthesis in epithelial cells. Nat Struct Mol Biol. 14:982-983.

• Bernot KM, Lee CH, Coulombe PA. (2005) A small surface hydrophobic stripe in the coiled coil domain of type I keratins mediates tetramer stability. J Cell Biol. 168:965-974.

• Cho MK, Lee CJ, Lee CH, Li SZ, Lim SK, Baik JH, Lee W. (2005) Structure and function of the potent cyclic and linear melanocortin analogues. J Struct Biol. 50:300-308.

Lee CH, Jung JW, Yee A, Arrowsmith CH, Lee W. (2004) Solution structure of a novel calcium binding protein, MTH1880, from Methanobacterium thermoautotrophicum. Protein Sci. 13:1148-1154.

• Jang HJ, Lee CH, Lee W, Kim YS. (2002) Two flexible loops in subtilisin-like thermophilic protease, thermicin, from Thermoanaerobacter yonseiensis. J Biochem Mol Biol. 35:498-507.

• Yee A, Chang X, Pineda-Lucena A, Wu B, Semesi A, Le B, Ramelot T, Lee GM, Bhattacharyya S, Gutierrez P, Denisov A, Lee CH, Cort JR, Kozlov G, Liao J, Finak G, Chen L, Wishart D, Lee W, McIntosh LP, Gehring K, Kennedy MA, Edwards AM, Arrowsmith CH. (2002) An NMR approach to structural proteomics. Proc Natl Acad Sci U S A. 99:1825-1830.

• Bang E, Lee CH, Yoon JB, Lee DW, Lee W. (2001) Solution structures of the N-terminal domain of histone H4. J Pept Res. 58:389-398.

• Lim S, Li S, Lee C, Yoon C, Baik J, Lee W. (2001) Minimization of MC1R selectivity by modification of the core structure of alpha-MSH-ND. Chem Biol. 8:857-870.

Lee CH, Hong H, Shin J, Jung M, Shin I, Yoon J, Lee W. (2000) NMR studies on novel antitumor drug candidates, deoxoartemisinin and carboxypropyldeoxo-artemisinin. Biochem Biophys Res Commun. 274:359-369.

특허

에리스로포이에틴 유래 펩티드의 세포손상방지에 효과를 통한 활용 (2018) 문제일, 이창훈, 김소연, 유승준, 이덕호

모노아실글리세롤 리파아제의 대량생산 방법 (2016) 이창훈, 김재우

전자책에 대한 질의 관리 장치 및 방법 (2015) 최경호, 이창훈, 박기성, 김대륜, 이석규, 이정아, 김성균, 최승호, 안흥주

전자책의 메모에 기초한 학업 관리 장치 및 방법 (2015) 박기성, 김성균, 안흥주, 이창훈, 김대륜, 최승호, 최경호, 이석규, 이정아

컨텐츠 모듈화 방법 및 장치 (2014) 박기성, 김장현, 남창훈, 최승호, 최성희, 김대륜, 김성균, 이정아, 최경호, 안흥주, 이두석, 이창훈, 노환진, 이석규

링크

https://www.facebook.com/changhun.lee.9843

https://openwetware.org/wiki/User:Chang-Hun_Lee


개인적인 관심사

http://pdb101.rcsb.org/

https://www.rcsb.org/news?year=2020&article=5e3c4bcba5007a04a313edcc